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Tuesday, January 31, 2012
Monday, January 30, 2012
Public Liability Insurance Explained | inthewake.org
Public Liability Insurance
Public Liability Insurance; if you?re reading this then you most likely already have it or you are thinking of taking out this insurance. Public Liability Insurance is as opposed to Employer?s Liability Insurance in that It?s not directly needed by law. On the other hand, It?s highly advised that you simply do invest in it due to the fact the law imposes what exactly is recognized as a ?duty of care? to employers and also the suppliers of goods. Failure to obtain Public Liability Insurance might also make you defenceless if a member of the public, or everyone else for that matter, attempts to make a claim against you; but even if you win the legal fees may possibly be crippling regardless.
But what does Public Liability Insurance do particularly? Properly Public Liability Insurance is usually a type of insurance which protects you, the employer, against any claims made by any third parties who make claims against you as a result of injury or harm to 1?s property as a result of your corporations activities. In addition, Public Liability Insurance may possibly not be needed by law but Employer?s Liability Insurance is so you may end up buying this insurance no matter whether you need it or not in order to be covered by Employer?s Liability Insurance.
If you are a small company who specialises in anything which entails directly associating using the common public then you really must be covered by this insurance. Furthermore, even when your modest enterprise is actually in your property and potential customers just pay a visit to your property you?re required to have Public Liability Insurance in case of injury to 1 of these customers. To clarify what injury in fact indicates; it will not just apply to any sort of physical or bodily injury, injury may also apply to humiliation and defamation.
But how should you decide what insurance is necessary and essential for your home business? There are actually two solutions to ascertain specifically what forms of insurance you?ll need. You can either go to an insurance broker and they are going to assess your company as a way to let you know what kind of insurance you need or you?ll be able to go to an insurance agent and they will also do exactly the same. The distinction in between the two, although, is the fact that the insurance broker is going to be acting in your most effective interests whereas the insurance agent are going to be operating for the most beneficial interests of their own business.
To sum up, although, if you?re a home business who offers in any way using the common public then you most likely will have to be covered by Public Liability Insurance. Alternatively, in the event you don?t cope with the general public but you nonetheless have staff then you can have to acquire Public Liability Insurance so that you can be covered by the Employer?s Liability Insurance anyway.
Click here for more information on Public Liability Insurance and What is Public Liability Insurance and Compare Public Liability Insurance
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This entry was posted in Coffins / Caskets and tagged Explained, Insurance, Liability, Public. Bookmark the permalink.Source: http://www.inthewake.org/public-liability-insurance-explained/
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SAG Awards 2012: John Cryer Talks Ashton Kutcher Vs. Charlie Sheen On 'Two And A Half Men' (VIDEO)
"Two And A Half Men" star John Cryer definitely feels a difference on set since Ashton Kutcher replaced the hit sitcom's former star Charlie Sheen.
On the red carpet at the Screen Actors Guild Awards on Sunday night, he told E! that Kutcher is "great. He's a clown. He is up for anything, willing to do anything... a great, great spirit."
When E! host Giulianna Rancic asked if things felt differently on set in this post-Sheen era, Cryer -- who was nominated for his first SAG award -- took a bit of a jab at his former co-star. "It's a little less suspenseful being on the set nowadays," he said with a laugh. "When you come into work, you're pretty sure [Kutcher's] going to be there. And nobody's pushed his car off a cliff or anything like that"
As for Sheen, who is currently working on his FX series "Anger Management," Cryer said, "I haven't spoken with him though. I wish him well. He's got a good team around him and I can't imagine he's not going to put out a good show."
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Sunday, January 29, 2012
British police arrest 4 in tabloid bribery probe (AP)
LONDON ? British police say they have arrested four people, including a police officer, on suspicion of corruption as part of an investigation into police bribery by a tabloid newspaper.
London's Metropolitan Police said two men aged 48 and one aged 56 were arrested early Saturday at homes in and around London.
The fourth, a 29-year-old police officer, was arrested at the London station where he works.
The investigation is running parallel to a police inquiry into phone hacking by Rupert Murdoch's now-defunct News of the World.
Police said the arrests were made as a result of information provided by Murdoch's News Corp.
A dozen people have now been arrested in the bribery probe, though none has yet been charged.
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UN nuclear officials want Iranian cooperation (AP)
VIENNA ? The head of a U.N. nuclear team traveling to Iran on Saturday urged the country to work with his mission on probing Tehran's alleged attempts to develop an atomic arms program, adding such cooperation is long overdue.
The unusually blunt comments by International Atomic Energy Deputy Director General Herman Nackaerts reflected the importance the IAEA is attaching to the chief focus of the trip ? ending more than three years of Iranian refusal to answer questions about such suspicions.
Ahead of departure, Nackaerts told reporters at Vienna airport he hopes Iran "will engage with us on all concerns."
"So we're looking forward to the start of a dialogue," he said: "A dialogue that is overdue since very long."
Diplomats said Iran had accepted the inclusion of two senior weapons experts ? Jacques Baute of France and Neville Whiting of South Africa ? with relatively little fuss. That suggests the Islamic Republic may be prepared to address some issues related to the allegations.
Also on the team is Rafael Grossi, IAEA chief Yukiya Amano's right-hand man.
Any progress would be significant.
Tehran has blocked IAEA attempts for more than three years to follow up on U.S. and other intelligence, dismissing the charges as baseless and insisting all its nuclear activities were peaceful and under IAEA purview.
Faced with Iranian stonewalling, the IAEA summarized its body of information in November, in a 13-page document drawing on 1,000 pages of intelligence. It stated then for the first time that some of the alleged experiments can have no other purpose than developing nuclear weapons.
Iran continues to deny the charges and no change in its position is expected during the three-day Tehran talks with IAEA officials. But even a decision to enter a discussion over the allegations would be a major departure from outright refusal to talk about them.
The diplomats said that the IAEA team was looking for permission to talk to key Iranian scientists suspected of weapons work, inspect documents relating to such suspected work and get commitments for future visits to sites linked to such allegations.
Iran says it is enriching only to generate energy. But it has also started producing uranium at a higher level than its main stockpile ? a move that would jump-start the creation of highly enriched, weapons-grade uranium, should it chose to go that route. And it is moving its higher-enriched operation into an underground bunker that it says is safe from attack.
__
AP video reporter Philipp Jenne contributed.
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Saturday, January 28, 2012
Tiger Woods shoots 66 to share lead in Abu Dhabi (AP)
ABU DHABI, United Arab Emirates ? Tiger Woods shot a 6-under 66 Saturday to grab a share of the lead at the Abu Dhabi Golf Championship, the latest sign that the 14-time major winner is returning to form after ending a two-year victory drought.
There wasn't a lot of fist pumping from Woods, who traded drama for consistency in racking up six birdies in a bogey-free round.
It was a memorable performance by the American, mostly for his ability to hit the fairways, tame the par 5s and sink clutch putts ? including a six-footer for birdie on the final hole.
"It just seemed like I didn't do a lot of things right but I didn't do a lot of things wrong today, it was just very consistent," Woods said. "You know, made a couple putts here and there ... I stayed away from trouble and tried to keep the ball towards the fat side of some of these pins and I think I did a pretty good job."
Woods moved to 11 under for the tournament and is tied with newcomer Robert Rock, who birdied his final two holes to earn the 117th-ranked Englishman a first-ever pairing with Woods for Sunday's finale.
Rory McIlroy (68), Peter Hanson (64), Francesco Molinari (66) and Paul Lawrie (68) were two shots back, with George Coetzee (65), James Kingston (67), overnight leader Thorbjorn Olesen (71) and Jean-Baptiste Gonnet (69) all a shot further back.
Woods is attempting to follow his season-ending victory at the Chevron World Challenge with another win here. He was two shots off the pace after the second round but started climbing the leaderboard Saturday with an opening birdie, followed by another on No. 7.
He stepped up his game on the back nine and grabbed a share of the lead after he narrowly missed an eagle putt on the 10th and settled for birdie. He briefly took the outright lead with a birdie on 14.
The crowd of several hundred cheered every birdie, with some yelling "Tiger's back."
Woods refused to talk about his victory chances, acknowledging too many players remain within striking distance.
"There's a ton of guys with a chance to win," Woods said. "You know, we have not separated ourselves from the field. The field is very bunched. I need to go out there and put together a solid round of golf, and I can't go out there and shoot even par and expect to win. I've got to go out there and go get it."
Rock, who got his first European Tour win last year in Italy in a playoff with Sergio Garcia, admitted he was star-struck at the prospect of teeing off alongside Woods, calling him "the best guy I've ever seen play golf."
The 34-year-old journeyman is relishing the chance to go head-to-head with one of golf's all-time greats.
"There's quite a lot of people out there (today) obviously following Tiger in the group in front of us. Hopefully we've got the same amount of people watching tomorrow, and we'll see how I cope with it," Rock said. "I just want to experience it. How many chances I'll get to do that, it's not clear."
Rock was one of several players who challenged Woods for the lead after overnight leader Olesen fell back.
Lawrie, the 1999 British Open champion, showed some of the form he displayed at the Dubai World Championship in December, where he finished second. He made birdie on 10 and 11 to tie Woods for the lead, fell back with bogeys on 14 and 17 and then recovered to birdie the 18th.
Molinari and Hanson also bounced back from opening round 74s to move into contention. Molinari had five birdies on his back nine, while the 47th-ranked Swede had eight birdies in his round ? including three on the last five holes ? in a bogey-free round to finish with the lowest score of the day.
"It was one of those days where you have the best job in the world," Hanson said. "Struck it nice, made four easy birdies on the par 5s and then a few more, and it felt pretty easy somehow."
U.S. Open champion McIlroy also is still in the mix, a day after he had two double bogeys, including on the 9th when he was penalized for brushing away sand in front of his ball. He only had one bogey to go with five birdies Saturday, but the 22-year-old Northern Irishman was forced to scramble several times to save par, including on the 18th when an errant drive went into nearby rocks and almost into a pond.
"I definitely felt today was a lot better than yesterday," McIlroy said. "I felt like I hit the ball a lot better. I feel that I made a couple of loose swings off the tee and obviously one on the last, and a couple others, but it's getting there. So hopefully I can just keep that going tomorrow and maybe get off to a fast start and put pressure on the guys in front of me."
Top-ranked Luke Donald (73) is 11 shots behind Woods, with No. 2-ranked Lee Westwood (68) seven off the lead.
___
Follow Michael Casey on Twitter at https://twitter.com/mcasey1
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Australian gov't, activists trade blame for clash
Australia's Prime Minister Julia Gillard, second from left, is escorted out for safety by body guards and police through a crowd of rowdy protesters following a ceremony to mark Australia's national day in Canberra, Australia, Thursday Jan. 26, 2012. Some 200 supporters of indigenous rights surrounded a Canberra restaurant and banged its windows on Thursday while Gillard and opposition leader Tony Abbott were inside officiating at an award ceremony. (AP Photo/Lukas Coch) AUSTRALIA OUT
Australia's Prime Minister Julia Gillard, second from left, is escorted out for safety by body guards and police through a crowd of rowdy protesters following a ceremony to mark Australia's national day in Canberra, Australia, Thursday Jan. 26, 2012. Some 200 supporters of indigenous rights surrounded a Canberra restaurant and banged its windows on Thursday while Gillard and opposition leader Tony Abbott were inside officiating at an award ceremony. (AP Photo/Lukas Coch) AUSTRALIA OUT
Prime Minister Julia Gillard is escorted out for safety by body guards and police through a crowd of rowdy protesters following a ceremony to mark Australia's national day in Canberra, Australia, Thursday Jan. 26, 2012. Some 200 supporters of indigenous rights surrounded a Canberra restaurant and banged its windows on Thursday while Gillard and opposition leader Tony Abbott were inside officiating at an award ceremony. (AP Photo/Lukas Coch) AUSTRALIA OUT
Prime Minister Julia Gillard, second from left, is escorted out for safety by body guards and police through a crowd of rowdy protesters following a ceremony to mark Australia's national day in Canberra, Australia, Thursday Jan. 26, 2012. Some 200 supporters of indigenous rights surrounded a Canberra restaurant and banged its windows on Thursday while Gillard and opposition leader Tony Abbott were inside officiating at an award ceremony. (AP Photo/Lukas Coch)
Aboriginal protesters from their Tent Embassy burn a U.S. flag during a protest outside Parliament House in Canberra, Australia, Friday, Jan. 27, 2012. Around 200 protesters marched and burned the flag in front of a wall of police in the protest that followed an angry clash with police Thursday outside a restaurant where Prime Minister Julia Gillard appeared at an event for Australia Day. (AP Photo/AAP Image, Alan Porritt) AUSTRALIA OUT, NO SALES
SYDNEY (AP) ? Authorities and indigenous-rights protesters blamed each other Friday for a heated clash in which bodyguards had to rush Prime Minister Julia Gillard out of an event marking the anniversary of British colonization.
Gillard stumbled in Thursday's fray and lost a shoe, which protesters scooped up after the rowdy demonstration in the capital Canberra. Aboriginal-rights supporters had surrounded a restaurant and banged on its windows while Gillard and opposition leader Tony Abbott were inside at an award ceremony to mark Australia Day.
Michael Outram, national manager of protection for the Australian Federal Police, said police may file charges against some of the protesters. Gillard said Friday that she was fine, but slammed the activists' actions.
"I've got no troubles at all with peaceful protests. ... What I utterly condemn is when protests turn violent the way we saw the violence yesterday, and particularly to disrupt an event which was to honor some extraordinary Australians," she said.
Protest leaders denied doing anything wrong, accused the police of manhandling protesters and said they planned to lodge a complaint against the officers involved.
"The Australian Federal Police came at us with force and we did not retaliate with force," protest spokeswoman Selina Daveys-Newry told reporters Friday. "We see straight through that little puppet play."
About 200 indigenous-rights supporters marched on the nation's Parliament House on Friday, burning an Australian flag in front of a wall of police and carrying signs with messages such as "All cops are bastards." No one was hurt and the protesters left minutes later.
The restaurant where Thursday's clash occurred is close to the so-called Aboriginal Tent Embassy, where the protesters had demonstrated peacefully earlier in the day. That long-standing, ramshackle collection of tents and temporary shelters is a center point of protests against Australia Day, which marks the arrival of the first fleet of British colonists in Sydney on Jan. 26, 1788. Many Aborigines call it Invasion Day because the land was settled without a treaty with traditional owners.
Outram defended the way Thursday's incident had been handled, saying police had no idea the protest ? which had been peaceful for much of the day ? would turn aggressive.
"We had no information or reason to suspect there was going to be any problem," Outram told reporters in Canberra.
Abbott was the focus of much of the protesters' rage. The Tent Embassy celebrated its 40th anniversary on Thursday, and Abbott had earlier angered activists by saying it was time the embassy "moved on." Abbott said Friday that his comment had been misinterpreted, and that he never meant to imply the embassy should be torn down.
Warren Mundine, a respected Aboriginal leader, denounced the actions of the protesters, saying they had overreacted.
"They are a fringe, radical group ? they're not the mainstream of indigenous Australians," Mundine said. "If you look at (Abbott's) words, they're pretty harmless and they don't even mention anything about moving the Tent Embassy."
Questions lingered, meanwhile, about the fate of Gillard's high-heeled blue suede shoe. There was talk about holding it for ransom or auctioning it off on eBay, but Tent Embassy founder Michael Anderson said at a press conference Friday that it would be returned to the prime minister.
Gillard didn't seem to care.
"It really doesn't worry me," she said with a grin. "I'm in a fortunate situation where I'm a woman with a few pairs of shoes."
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Friday, January 27, 2012
RIM BlackBerry Curve 9370 (Verizon Wireless)
RIM may be struggling to revamp its smartphone OS, but that's good news if you don't like change?or just want a cell phone bargain. The BlackBerry Curve 9370 ($99.99) doesn't offer the flash, the speed, or the app catalog of other smartphone platforms, but it can do just about everything most users need, and in an unusually svelte form factor. The BlackBerry Curve 9370 is a fitting send off for BlackBerry 7 OS in the face of the upcoming QNX-based BlackBerry 10, assuming RIM can finally get its act together. But if you like apps, you should still buy an Android or an iPhone.
Design, Call Quality, and Apps
The Curve 9370 measures 4.3 by 2.4 by 0.4 inches (HWD) and weighs 3.5 ounces. RIM has been refining this design for years, and it shows; keyboarded smartphones don't get much smaller or lighter than this. The Curve 9370 is made mostly of black plastic, with smoked chrome accents and a textured rubber back panel. The non-touch 480-by-360-pixel LCD measures 2.4 inches diagonally, and looks reasonably bright and colorful. Below the screen are RIM's now-trademark touch pad and four function keys. The four-row QWERTY keyboard is slightly curved and features large, well-separated keys. The keys aren't as raised as before, but the click feel is tuned just right. If you can get your hands around a small device like this one, it's super-easy to type fast.
A true world phone, the Curve 9370 comes?with dual-band EV-DO Rev A (850/1900 MHz) and quad-band EDGE (850/900/1800/1900 MHz) support, although it's limited to 2G data speeds overseas. You also get 802.11b/g/n Wi-Fi. Reception was fine, and voice quality was good in my tests, especially through the earpiece; voices sounded loud and bright, with no background noise. Transmissions through the microphone were also punchy, although the mic picked up a lot of street noise. Calls sounded fine through a Jawbone Era ($129, 4.5 stars), and voice dialing worked perfectly over Bluetooth. The speakerphone was a disappointment, with barely enough volume to overcome a desk fan. It's less powerful than Curves of old, and a clear consequence of the thinner design. Battery life was average at 5 hours and 4 minutes of talk time.
The 800MHz CPU is plenty for this application, and keeps the Curve 9370 moving at a good clip in day-to-day operations. BlackBerry 7 OS (Free, 3 stars) is a modest update of an established and now-dated OS. You get push e-mail for up to 10 Web or work accounts, plus built-in Office document editing and a vastly improved WebKit browser. The preloaded BlackBerry Messenger 6, BBM Music, and Social Feeds apps give the Curve some much-needed social connectivity. Verizon VZ Navigator offers voice-enabled, turn-by-turn GPS directions, but the new NFC chip does nothing for now, as Verizon is prepping its own service and doesn't allow Google Wallet support. BlackBerry App World is still an embarrassment, with a poor selection of apps and unreliable downloads, although by this point many popular apps now have BlackBerry versions.?
Multimedia, Camera, and Conclusions
BlackBerrys continue to make good music players, and the Curve 9370 is no exception, with its standard-size 3.5mm headphone jack and microSD memory card slot underneath the battery cover. My 32GB SanDisk card worked fine, RIM throws in a 2GB card, and there's 202MB of free internal app memory and 308MB of free media storage.
Music tracks sounded clear, if a tad bright, over Samsung Modus HM6450 Bluetooth headphones ($99, 4 stars). The music player is about as easy to use as it could be given the phone's form factor, with large album art thumbnails, although the sensitive trackpad makes navigation a chore; at least you can tune the level of sensitivity. BlackBerry Desktop Software works well for syncing media, including iTunes playlists, and comes in both PC and Mac versions. Standalone 320-by-240 QVGA and VGA MP4 and H.264 videos played fine, but anything greater (as well as DivX and Xvid files) wouldn't play.
The 5-megapixel camera has no auto-focus, although it includes an LED flash, face detection, image stabilization, and geotagging. Test photos were sharp and detailed, even indoors, although the amount of noise increased considerably as the lights dimmed. The flash blew out highlights and lit the room unevenly. Recorded videos maxed out at 640-by-480-pixel (standard VGA) and looked a little dark, but played smoothly at 30 frames per second. Kicking on image stabilization knocked the rate down a tick to 29 frames per second, although I still saw some shakes even with it on.?
If you want fast push email on the go and a hardware keyboard, the Curve 9370 is a solid choice, particularly if you travel overseas often but must have Verizon in the U.S. Having said that, keyboarded smartphones haven't seen much love on Verizon Wireless lately; I'd suggest holding out for the keyboarded Motorola Droid 4, which RIM promises will hit in the coming weeks to replace the Droid 3 ($49.99, 3 stars). The Droid 4 packs a slide-out QWERTY keyboard with edge-lit, sharply cut keys, plus an LTE radio, dual-core processor, and 4-inch capacitive touch screen; the Droid 3 lacks LTE and has the older keyboard, but it's still a good budget pick and now $50 less expensive than the Curve 9370. Otherwise, the BlackBerry Bold 9930 ($249.99, 3 stars) is faster, has a sharper screen with touch capability, and records 720p video, but it's larger, heavier, and more expensive than the Curve 9370.?
Benchmarks
Continuous talk time: 5 hours 4 minutes
More Cell Phone Reviews:
??? RIM BlackBerry Curve 9370 (Verizon Wireless)
??? Samsung Replenish (Boost Mobile)
??? HTC Titan (AT&T)
??? PCD Wrangler (U.S. Cellular)
??? Nokia Lumia 710 (T-Mobile)
?? more
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Google Music now lets you download your entire library
Google Music now lets you download your entire library originally appeared on Engadget on Fri, 27 Jan 2012 07:27:00 EDT. Please see our terms for use of feeds.
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Thursday, January 26, 2012
Zusi's goal lift US men to 1-0 win over Panama
By The Associated Press
updated 10:42 p.m. ET Jan. 25, 2012
Graham Zusi scored his first international goal in the eighth minute, and the United States beat Panama 1-0 in an exhibition game Wednesday night at Panama City for its third straight win.
Using mostly backups while the regulars remained with their European clubs and playing nearly the entire second half a man short, the Americans evened their record at 4-4-1 under Jurgen Klinsmann, who replaced Bob Bradley as coach last summer.
Panama, which upset the U.S. in the first round of last year's CONCACAF Gold Cup, had a man advantage after Geoff Cameron received a red card in the 52nd minute for shoving Blas Perez from behind on a breakaway just outside the penalty area.
Perez nearly tied it in the 78th but sent a short downward header wide.
Other than the goal, the Americans rarely threatened ? the U.S. didn't have its first corner kick until the fifth minute of stoppage time in the second half, just before the final whistle.
And goalkeeper Nick Rimando made several difficult saves to prevent the hosts from scoring.
During a three-week training camp, Klinsmann got to test the depth of his player pool as the Americans prepare for the start of World Cup qualifying on June 8 against Antigua and Barbuda.
Klinsmann figures to have most his top players for the Americans' next game, against Italy at Genoa on Feb. 29.
Zusi, a 25-year-old midfielder with Major League Soccer's Sporting Kansas City, made his national debut in Saturday's 1-0 win over Venezuela at Glendale, Ariz.
His goal came after left back Zach Loyd's cross fell at Teal Bunbury at the top of the 6-yard box and appeared to bounce off him to Zusi, who slammed it in with a right-footed shot from 7 yards.
Rimando, making his first national team appearance in a year, dove midway through the first half to block Luis Renteria's point-blank shot, which bounded in front of the net. Rimando then got up and managed to poke the ball away before the rebound could be knocked in.
Jermaine Jones nearly made it 2-0 in the 30th, but goalkeeper Luis Mejia parried his 30-yard shot, then dived back to save Chris Wondolowski's header at the goal line.
Five minutes later, Rimando athletically got his left leg out to block Perez's close-range shot.
Ricardo Clark earned his first national team start in 19 months after scoring in the seventh minute of stoppage against Venezuela.
Clark, who replaced Jeff Larentowicz in the midfield, had not started for the Americans since June 26, 2010, when he was stripped of the ball leading to Ghana's opening goal in the 2-1 overtime loss that eliminated the U.S. from the World Cup.
Klinsmann switched to a 4-4-2 formation from the 3-5-1 he began with last weekend and made four changes to his starting lineup, also inserting Rimando, Loyd and Wondolowski in place of Bill Hamid, Heath Pearce and Benny Feilhaber. Rimando, Loyd and Wondolowski started for the first time since the 1-1 tie against Chile on Jan. 22, 2011.
Pearce replaced Loyd in the 41st minute and Sean Johnson took over for Rimando at the start of the second half in his first appearance since the Chile match. Defender Jeff Parke made his debut in the 55th minute, coming in for Wondolowski after Cameron's red card.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsAFP - Getty ImagesBarca holds off Madrid rally
Pedro Rodriguez and Daniel Alves scored first-half goals, and Barcelona held off a spirited Real Madrid comeback attempt to eliminate the defending Copa del Rey champion with a 2-2 tie Wednesday night.
Do-or-die
The U.S. women's soccer team was still on the field, having dispatched rival Mexico, when Abby Wambach gathered her teammates for a little speech.
Source: http://nbcsports.msnbc.com/id/46141711/ns/sports-soccer/
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Google introduces privacy changes (cue the backlash)
On March 1, Google will roll out a new, streamlined privacy policy. And some critics are already up in arms.?
On March 1, Google will introduce a new, streamlined terms of service and privacy policy, which takes approximately 60 separate policies for various Google products, and rolls them into a single "much more readable" document. The move comes as Google seeks to expand Search Plus Your World ? an initiative that mixes Google+ posts and personal photos with more traditional search results.?
Skip to next paragraph"The main change is for users with Google Accounts," Google's Alma Whitten wrote in a post on the company blog yesterday.?"Our new Privacy Policy makes clear that, if you?re signed in, we may combine information you've provided from one service with information from other services. In short, we?ll treat you as a single user across all our products, which will mean a simpler, more intuitive Google experience."
But as Cecilia Kang notes over at the Washington Post, the new policies have critics worried ? not least because the new policies will not come with an opt-out provision. A user signing up for Gmail, might not know the "content of his or her messages could affect the experience on seemingly unrelated Web sites such as YouTube," Kang writes.?
And plenty of lawmakers agree.?
"The lack of opt-out means users cannot pick and choose which data they want integrated into their Google profiles," Sen. Richard Blumenthal, a Democrat from Connecticut, wrote this week in a blog post (hat tip to Politico). "Private email messages might contain any number of personal, embarrassing or otherwise damaging information, and Google's attempts to amplify and contextualize this information through targeted ads, maps suggestions or calendar reminders could have negative consequences for users."
Over at Computerworld, Barbara Krasnoff points out that the new policies will be of particular interest to owners of devices such as the Galaxy Nexus smart phone, "which is pretty much useless outside of the Google netverse." Galaxy Nexus owner with a strong objection to the recent changes instituted by Google? Well, you're in trouble.?
"I must admit, the idea of being completely unable to opt out of specific privacy issues has me very troubled," Krasnoff writes. "My immediate reaction is to read Google's policies, check out some of the more knowledgeable commentators on the subject, and if I find that I do agree with those privacy activists who believe that Google has stepped too far over the line, to join those hoping to pressure the company to alter its new policy."?
For more tech news, follow us on?Twitter @venturenaut. And don?t forget to sign up for the weekly?BizTech newsletter.
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Wednesday, January 25, 2012
Video: Matthews: Gingrich ? just what the ?devil ordered??
Tablets, e-readers in 1 of every 4 hands now
Get an iPad, Kindle Fire or Nook Tablet over the holidays? You're not alone: Tablet and e-reader ownership increased by nearly double over the holidays, and more than 1 out of every 4 Americans now has one of the devices, according to a new study.
Source: http://www.msnbc.msn.com/id/3036697/vp/46107211#46107211
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Paterno loses battle with lung cancer
Legenday Penn State coach, 85, leads all in college wins
Getty ImagesPenn State coach Joe Paterno celebrates his 324th career win after defeating Ohio State on Oct. 27, 2001.
By GENARO C. ARMAS
updated 12:38 p.m. ET Jan. 22, 2012
STATE COLLEGE, Pa. - Joe Paterno, the longtime Penn State coach who won more American football games than anyone in major college history but was fired amid a child sex abuse scandal that scarred his reputation for winning with integrity, died Sunday. He was 85.
His family released a statement Sunday morning to announce his death: "His loss leaves a void in our lives that will never be filled."
"He died as he lived," the statement said. "He fought hard until the end, stayed positive, thought only of others and constantly reminded everyone of how blessed his life had been. His ambitions were far reaching, but he never believed he had to leave this Happy Valley to achieve them. He was a man devoted to his family, his university, his players and his community."
Two police officers were stationed to block traffic on the street where Paterno's modest ranch home stands next to a local park. The officers said the family had asked there be no public gathering outside the house, still decorated with a Christmas wreath, so Paterno's relatives could grieve privately. And, indeed, the street was quiet on a cold winter day.
Paterno's sons, Scott and Jay, arrived separately at the house late Sunday morning. Jay Paterno, who served as his father's quarterbacks coach, was crying.
Paterno built his program on the credo "Success with Honor," and he found both. The man known as "JoePa" won 409 games and took the Nittany Lions to 37 bowl games and two national championships. More than 250 of the players he coached went on to the NFL."He will go down as the greatest football coach in the history of the game," Ohio State coach Urban Meyer said after his former team, the Florida Gators, beat Penn State 37-24 in the 2011 Outback Bowl.
Paterno's son Scott said on Nov. 18 that his father was being treated for lung cancer. The cancer was diagnosed during a follow-up visit for a bronchial illness. A few weeks after that revelation, Paterno also broke his pelvis after a fall but did not need surgery.
Paterno had been in the hospital since Jan. 13 for observation for what his family had called minor complications from his cancer treatments. Not long before that, he conducted his only interview since losing his job, with The Washington Post. Paterno was described as frail then, speaking mostly in a whisper and wearing a wig. The second half of the two-day interview was conducted at his bedside.
"As the last 61 years have shown, Joe made an incredible impact," said the statement from the family. "That impact has been felt and appreciated by our family in the form of thousands of letters and well wishes along with countless acts of kindness from people whose lives he touched. It is evident also in the thousands of successful student athletes who have gone on to multiply that impact as they spread out across the country."
The final days of Paterno's Penn State career were easily the toughest in his 61 years with the university and 46 seasons as head football coach.
It was because Paterno was a such a sainted figure ? more memorable than any of his players and one of the best-known coaches in all of sports ? that his downfall was so startling. During one breathtaking week in early November, Paterno was engulfed by a scandal and forced from his job, because he failed to go to the police in 2002 when told a young boy was molested inside the football complex."I didn't know which way to go ... and rather than get in there and make a mistake," he said in the Post interview.
Jerry Sandusky, the former defensive coordinator expected to succeed Paterno before retiring in 1999, was charged with sexually assaulting 10 boys over 15 years. Two university officials stepped down after they were charged with perjury following a grand jury investigation of Sandusky. But attention quickly focused on an alleged rape that took place in a shower in the football building, witnessed by Mike McQueary, a graduate assistant at the time.
McQueary testified that he had seen Sandusky attacking the child and that he had told Paterno, who waited a day before alerting school authorities. Police were never called and the state's top cop later said Paterno failed to execute his moral responsibility by not contacting police.
"You know, (McQueary) didn't want to get specific," Paterno said in the Post interview. "And to be frank with you I don't know that it would have done any good, because I never heard of, of, rape and a man. So I just did what I thought was best. I talked to people that I thought would be, if there was a problem, that would be following up on it."
On the morning of Nov. 9, Paterno said he would retire following the 2011 season. He also said he was "absolutely devastated" by the abuse case.
"This is a tragedy," the coach said. "It is one of the great sorrows of my life. With the benefit of hindsight, I wish I had done more."
But the university trustees faced a crisis, and in an emergency meeting that night, they fired Paterno, effective immediately. Graham Spanier, one of the longest-serving university presidents in the nation, also was dismissed.
According to Lanny Davis, an attorney retained by the trustees as an adviser, board vice chairman John Surma regretted having to tell Paterno the decision over the phone.
The university handed the football team to one of Paterno's assistants, Tom Bradley, who said Paterno "will go down in history as one of the greatest men, who maybe most of you know as a great football coach."
Thick, smoky-lens glasses, rolled up khakis, jet-black sneakers, blue windbreaker ? Paterno was easy to spot on the sidelines. His teams were just as easy to spot on the field; their white helmets and classic blue and white uniforms had the same old-school look as the coach.
Paterno believed success was not measured entirely on the field. From his idealistic early days, he had implemented what he called a "grand experiment" ? to graduate more players while maintaining success on the field.
He was a frequent speaker on ethics in sports, a conscience for a world often infiltrated by scandal and shady characters.
His teams consistently ranked among the best in the Big Ten for graduating players. As of 2011, it had 49 academic All-Americans, the third-highest among schools in the Football Bowl Subdivision. All but two played under Paterno.
"He teaches us about really just growing up and being a man," former linebacker Paul Posluszny, now with the NFL's Jacksonville Jaguars, once said. "Besides the football, he's preparing us to be good men in life."
Paterno certainly had detractors, as well. One former Penn State professor called his high-minded words on academics a farce. He was criticized for making broad critiques about the wrongs in college football without providing specifics. A former administrator said his players often got special treatment compared to non-athletes. His coaching style often was considered too conservative. Some thought he held on to his job too long. There was a push to move him out in 2004 but it failed.
But the critics were in the minority, and his program was never cited for major NCAA violations. However, the child sexual abuse scandal prompted separate investigations by the U.S. Department of Education and the NCAA into the school's handling.
Paterno played quarterback and cornerback for Brown University and set a defensive record with 14 career interceptions, a distinction he boasted about to his teams all the way into his 80s. He graduated in 1950 with plans to go to law school. He said his father hoped he would someday be president.
When he was 23, a former coach at Brown was moving to Penn State to become the head coach and persuaded Paterno to come with him as an assistant.
"I had no intention to coach when I got out of Brown," Paterno said in 2007 at Beaver Stadium in an interview before being inducted into the Hall of Fame. "Come to this hick town? From Brooklyn?"
In 1963, he was offered a job by the late Al Davis ? $18,000, triple his salary at Penn State, plus a car to become general manager and coach of the AFL's Oakland Raiders. He said no. Rip Engle retired as Penn State head coach three years later, and Paterno took over.
At the time, the Lions were considered "Eastern football" ? inferior ? and Paterno courted newspaper coverage to raise the team's profile. In 1967, PSU began a 30-0-1 streak.
But Penn State couldn't get to the top of the polls. The Lions finished second in 1968 and 1969 despite perfect records. They went 12-0 in 1973 and finished fifth. Texas edged them in 1969 after President Richard Nixon, impressed with the Longhorns' bowl performance, declared them No. 1.
"I'd like to know," Paterno said later, "how could the president know so little about Watergate in 1973, and so much about college football in 1969?"
A national title finally came in 1982, in a 27-23 win over Georgia at the Sugar Bowl. Penn State won another in 1986 after the Lions picked off Vinny Testaverde five times and beat Miami 14-10 in the Fiesta Bowl.
They have made several title runs since then, including a 2005 run to the Orange Bowl and an 11-1 campaign in 2008 that earned them a berth in the Rose Bowl, where they lost 37-23 to Southern California.
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Source: http://nbcsports.msnbc.com/id/46085007/ns/sports-college_football/
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Tuesday, January 24, 2012
Halle Berry?s Baby-Daddy Being Investigated For Child Endangerment
Halle Berry’s Baby-Daddy Being Investigated For Child Endangerment
Halle Berry is taking her ex-boyfriend and baby-daddy, model Gabriel Aubry, to court on Tuesday in an emergency hearing over claims he pushed their daughter’s [...]
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Heidi Klum Filing For Divorce From Seal
Heidi Klum Filing For Divorce From Seal
Supermodel Heidi Klum is reportedly filing for divorce from singer Seal. But why would one of Hollywood’s most lovey-dovey couples be calling it quits? Heidi, [...]
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Monday, January 23, 2012
Gingrich upends Republican race in South Carolina (Reuters)
COLUMBIA, South Carolina (Reuters) ? Newt Gingrich jolted the Republican presidential race on Saturday with a convincing come-from-behind victory in South Carolina, where voters rejected frontrunner Mitt Romney's pitch that he is the best bet to fix a broken economy and defeat President Barack Obama.
Gingrich's win injects unexpected volatility into a Republican nominating race that until this week appeared to be a coronation for Romney, the former Massachusetts governor and private-equity chief.
Three different candidates now have won the first three contests in the state-by-state battle for the Republican presidential nomination to face Obama, a Democrat, on November 6.
Former senator Rick Santorum won the Iowa caucuses on January 3 and Romney won the New Hampshire primary on January 10. Gingrich fared poorly in both those states and had trailed badly in South Carolina polls.
Riding a series of feisty debate performances, Gingrich captured the lingering unease of conservative voters in South Carolina who view Romney's moderate past and shifting policy stances with suspicion. The former speaker of the U.S. House of Representatives argued that he would be able to better articulate the party's conservative ideals.
With 65 percent of the vote counted, Gingrich had pulled in 41 percent of the vote, followed by Romney with 26 percent, networks reported. Santorum was in third with 18 percent and U.S. congressman Ron Paul in fourth with 13 percent.
Gingrich contrasted his sometimes-chaotic management style with Romney's buttoned-down approach, arguing that his campaign was powered by ideas rather than logistics.
U.S. television networks declared Gingrich the winner shortly after polls closed at 7 p.m. EST (0000 GMT).
"We have a very real chance on an idea basis as conservatives to offer a better future for the American people. We have an ability to reach out to lots of people and communicate with them without millions of dollars of paid advertising," Gingrich said on Fox Business Network.
"This race is getting to be even more interesting," Romney told supporters.
"We're now three contests into a long primary season," he added in a speech in which he took several shots at Gingrich, including condemning Republican rivals for assaulting free enterprise as they criticized his business resume.
FLORIDA IS NEXT
The next contest is the Florida primary on January 31. It will be the largest state yet in the nomination battle and one that will require the candidates to spend quite a bit of money on advertising.
Romney starts off with a wide lead in the polls in Florida and a distinct edge in logistics and fund-raising, which will be crucial in a state that has 10 separate media markets.
A drawn-out Republican contest would likely help Obama as Republican candidates would continue to spend time and money attacking each other.
Obama, who does not face a primary challenger, will have his turn in the spotlight on Tuesday with his State of the Union address. In a message to supporters on Saturday, he said the speech would focus on "building an economy that works for everybody, not just a wealthy few.
Animosity between Gingrich and Romney has been festering since December, when a group supporting Romney launched a blitz of negative TV ads in Iowa that effectively ruined Gingrich's campaign there.
In South Carolina, a state with a reputation for rough and tumble politics, the gloves came off.
Gingrich attacked Romney's business record and reluctance to release personal tax information, while Romney pointed to Gingrich's past ethics lapses and alluded to his messy personal life.
Voters said they were overwhelmingly focused on fixing the sluggish economy and finding the strongest candidate to defeat Obama. Some 78 percent said they were "very worried" about the economy and 45 percent said that the most important trait in a candidate was the ability to beat Obama, according to exit polls released by CNN.
Those issues are the twin pillars of Romney's candidacy.
Romney had developed an aura of inevitability after strong showings in the first two nominating contests, and he led South Carolina polls by 10 percentage points a week ago.
He suffered a setback on Thursday when Iowa officials declared in a recount that he had come in second place in that state's January 3 contest, behind Santorum, instead of winning narrowly as initially announced.
Romney is among the richest men ever to run for the U.S. presidency and his stewardship of the private equity firm Bain Capital has been criticized by Gingrich and others.
"If Republican leaders want to join this president in demonizing success and disparaging conservative values then they are not going to be fit to be our nominee," Romney told supporters.
Voters said they viewed Romney's business background as an asset. But he waffled this week when asked whether he would release his tax records, and acknowledged that he pays a much lower tax rate than many Americans.
'PUNCH IN THE MOUTH'
"This is the punch in the mouth/wake up call Romney needed if he wanted to be a strong general election candidate," Republican strategist Ford O'Connell said in a Twitter message, referring to the South Carolina results.
Romney attacked Gingrich's ties to mortgage giant Freddie Mac and criticized his time in the nation's capital. His campaign also highlighted Gingrich's $300,000 fine due to ethics lapses while serving as House speaker 15 years ago.
The thrice-married Gingrich has fended off publicity about his turbulent marital history. On Thursday, he rejected his second wife's accusation that he had asked her for an "open marriage" while he was having an affair with another woman in the 1990s.
South Carolina has been a tough state for Romney's presidential ambitions. In his previous run for the White House in 2008, Romney finished a poor fourth, with just 15 percent of the vote, behind winner and eventual Republican nominee John McCain. McCain endorsed Romney in the current campaign.
The winner of South Carolina's Republican presidential primary has gone on to win the party's nomination in every presidential election since 1980.
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Sunday, January 22, 2012
6 killed in Afghanistan were Hawaii-based Marines
HONOLULU (AP) ? All six Marines killed in the crash of a U.S. helicopter in Afghanistan were based in Hawaii, a Hawaii congresswoman said Friday.
The CH-53D helicopter crashed Thursday in Afghanistan's southern province of Helmand.
U.S. Rep. Colleen Hanabusa, a member of the House Armed Services Committee, said Friday she's saddened to hear of the deaths. Her spokeswoman, Ashley Nagaoka Boylan, said the congresswoman was notified Thursday evening that all six Marines were Hawaii-based.
"All who have called Hawaii home are part of our island ohana, and every loss like this touches us deeply," Hanabusa said in a statement, using the Hawaiian word for family.
A senior U.S. defense official confirmed all six were Marines on condition of anonymity because the U.S. command in Afghanistan had not yet publicly released details.
The Vietnam War-era helicopter is the same model as one that crashed and killed a Marine in a bay off Hawaii on March 29. An investigation later revealed mechanical failure caused that accident.
The defense official said there is no indication that the helicopter in Afghanistan was hit by enemy fire.
Thursday's crash was the deadliest in Afghanistan since August, when 30 American troops died after a Chinook helicopter was apparently shot down in Wardak province in the center of the country.
The cause of the latest crash is still being investigated, but a statement issued by the NATO international military coalition said there was no enemy activity in the area when it happened.
German Brig. Gen. Carsten Jacobson, a spokesman for the NATO coalition in Kabul, said officials were looking at a "technical fault" as the possible culprit.
"The helicopter is one of the safest forms of transport," Jacobson said. He said not only does it protect troops the danger of roadside bombs on the ground, but it is well-tested, well-proven way to travel.
CH-53D Sea Stallion helicopters were first used in the 1960s, and the Marine Corps used them in the Vietnam War.
All Sea Stallions still used operationally are stationed at Marine Corps Base Hawaii in Kaneohe Bay. The military plans to replace them with the MV-22 Osprey.
"The loss of the six U.S. Marines in yesterday's helicopter crash in Afghanistan comes as tragic news for our island community and our nation," U.S. Rep. Mazie K. Hirono, of Hawaii, said in a statement. "We owe them and all of our brave servicemen and women a debt of gratitude for their dedication to our country."
In 2005, the same base lost 27 Marines when a CH-53E Super Stallion deployed to Iraq crashed during a desert sandstorm. Altogether, 30 Marines and a Navy medic were killed in that crash.
___
AP National Security Writer Robert Burns in Washington contributed to this report.
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Costa CEO says captain misled company, crew
In this undated underwater photo released by Carabinieri (Italian paramilitary police) Friday, Jan. 20, 2012 two Carabinieri scuba divers swim next to the Costa Concordia cruise ship's bell, off the tiny Giglio island, Italy. The $450 million Costa Concordia was carrying more than 4,200 passengers and crew when it slammed into well-marked rocks off the island of Giglio after the captain made an unauthorized diversion from his programmed route. The ship then keeled over on its side. (AP Photo/Carabinieri)
In this undated underwater photo released by Carabinieri (Italian paramilitary police) Friday, Jan. 20, 2012 two Carabinieri scuba divers swim next to the Costa Concordia cruise ship's bell, off the tiny Giglio island, Italy. The $450 million Costa Concordia was carrying more than 4,200 passengers and crew when it slammed into well-marked rocks off the island of Giglio after the captain made an unauthorized diversion from his programmed route. The ship then keeled over on its side. (AP Photo/Carabinieri)
Rescuers approach the grounded Costa Concordia cruise ship off the tiny Tuscan island of Giglio, Italy, Friday, Jan. 20, 2012. The cruise ship grounded off Tuscany shifted again on its rocky perch Friday, forcing the suspension of diving search operations for the 21 people still missing and raising concerns about the stability of the ship's resting place. (AP Photo/Gregorio Borgia)
People take photographs of the grounded Costa Concordia cruise ship off the tiny Tuscan island of Giglio, Italy, Friday, Jan. 20, 2012. The cruise ship grounded off Tuscany shifted again on its rocky perch Friday, forcing the suspension of diving search operations for the 21 people still missing and raising concerns about the stability of the ship's resting place. (AP Photo/Gregorio Borgia)
People watch the Costa Concordia cruise liner off the tiny Tuscan island of Giglio, Italy, Friday, Jan. 20, 2012. The cruise ship grounded off Tuscany shifted again on its rocky perch Friday, forcing the suspension of diving search operations for the 21 people still missing and raising concerns about the stability of the ship's resting place. (AP Photo/Gregorio Borgia)
People look out toward the Costa Concordia cruise liner off the tiny Tuscan island of Giglio, Italy, Friday, Jan. 20, 2012. The cruise ship grounded off Tuscany shifted again on its rocky perch Friday, forcing the supension of diving search operations for the 21 people still missing and raising concerns about the stability of the ship's resting place. (AP Photo/Gregorio Borgia)
ROME (AP) ? The cruise captain who grounded the Costa Concordia off the Tuscan coast with 4,200 people on board did not relay correct information either to the company or crew after the ship hit rocks, the cruise ship owner's CEO said Friday as the search resumed for 21 missing passengers.
CEO Pierluigi Foschi told Italian state TV that the company spoke to the captain at 10:05 p.m. (2105 GMT; 4:05 p.m. EST), some 20 minutes after the ship ran aground on Jan. 13, but could not offer proper assistance because the captain's description "did not correspond to the truth."
Capt. Francesco Schettino said only that he had "problems" on board but did not mention hitting a reef.
Likewise, Foschi said crew members were not informed of the gravity of the situation.
Passenger video shown on Italian TV indicates crew members telling passengers to go to their cabins as late as 10:25 p.m. (2125 GMT; 4:25 p.m. EST). The abandon ship alarm sounded just before 11:00 p.m. (2200 GMT; 5:00 p.m. EST).
"That's because they also did not receive correct information on the gravity of the situation," Foschi said.
The $450 million Costa Concordia was carrying more than 4,200 passengers and crew when it slammed into well-charted rocks off the island of Giglio a week ago. Eleven people have been confirmed dead.
The Concordia shifted again on its rocky perch Friday, forcing the suspension of diving search operations for the 21 people still missing and raising concerns about the stability of the ship's resting place. But the search in areas above the waterline resumed in the evening after the ship was deemed stable.
The remarks by Costa CEO Foschi are the latest to indicate a lack of proper communication with authorities on land as the emergency unfolded.
An audiotape of the Concordia's first contact with maritime authorities has a Concordia office repeatedly replying that the ship had experienced a blackout, even though it had hit the reef more than half an hour earlier.
Italian media reported the officer on the call was Schettino, but that could not be independently confirmed.
Costa Crociere SpA, which offered support to the captain in the hours after the emergency, has now turned its back on the man who is under investigation for manslaughter, causing a shipwreck and abandoning his ship. Schettino, who was jailed after he left the ship, is under house arrest near Naples.
Costa in recent days has suspended Schettino, announced it is no longer paying his legal fees and has signed on as a civil party in the prosecution, a move that positions it as an injured party and would allow it to seek damages in the case of a guilty verdict.
Coast Guard spokesman Cmdr. Cosimo Nicastro said crews will evaluate the ship's stability Saturday morning to see if the diving operation can resume, focusing on an area where passengers would have sought lifeboats, Nicastro said.
It was not clear if the slight movements registered by sensors placed on board the Costa Concordia were just vibrations as the ship settles on the rocks off the Tuscan island of Giglio or if the massive ocean liner is slowly slipping off the reef. Salvage experts suggest it could be because of pockets of air gradually escaping.
The sensors detected that the ship's bow was moving about 15 millimeters (half an inch) an hour and the stern about 7 millimeters (one-quarter inch) an hour, said Nicola Casagli of the University of Florence, who was called in by Italian authorities to monitor the ship's stability.
The Concordia's movements are being watched since any significant shift could be dangerous for divers trying to locate those missing since the Concordia ran aground Jan. 13. An additional fear is that movement could damage tanks holding a 500,000 gallons of fuel oil and lead to leaks.
The sea floor drops off sharply a few meters (yards) from where the ship is resting, and Italy's environment minister has warned it risks sinking.
On Friday, relatives of some of the 21 missing were at Giglio's port getting briefings from rescue teams.
Casagli told Sky TG24 that some movement in the Concordia was only natural given the immense weight of the steel-hulled ship, which is being held in place by two huge rocks at bow and stern.
But the latest movements indicate it isn't stable, he said. "These are small, regular movements that are being monitored because they're going in the same direction," he told Sky.
Late Thursday, Carnival Corp., the U.S.-based company that owns Costa, announced it was conducting a comprehensive audit of all 10 of its cruise lines to review safety and emergency response procedures in the wake of the Costa disaster. The evacuation was chaotic and the alarm to abandon the ship was sounded after the Concordia had capsized too much to get many life boats down.
___
Colleen Barry reported from Milan. Andrea Foa contributed from Giglio, Italy.
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Saturday, January 21, 2012
Penn researchers help solve questions about Ethiopians' high-altitude adaptations
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Public release date: 20-Jan-2012[ | E-mail |
Share ] Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
PHILADELPHIA -- Over many generations, people living in the high-altitude regions of the Andes or on the Tibetan Plateau have adapted to life in low-oxygen conditions. Living with such a distinct and powerful selective pressure has made these populations a textbook example of evolution in action, but exactly how their genes convey a survival advantage remains an open question. Now, a University of Pennsylvania team has made new inroads to answering this question with the first genome-wide study of high-altitude adaptations within the third major population to possess them: the Amhara people of the Ethiopian Highlands.
Surprisingly, all three groups' adaptations appear to involve different genetic mutations, an example of convergent evolution.
"These three groups took different genetic approaches to solving the same problem," said senior author Sarah Tishkoff, a Penn Integrates Knowledge professor with appointments in the genetics department in Penn's Perelman School of Medicine and the biology department in the School of Arts and Sciences.
In addition to Tishkoff, the research was led by Laura B. Scheinfeldt, a research scientist in the genetics department at the Perelman medical school. Other members of the genetics department who contributed to the research are Sameer Soi, Simon Thompson, Alessia Ranciaro, William Beggs, Charla Lambert and Joseph P. Jarvis.
The Penn team collaborated with Dawit Wolde Meskel, Dawit Abate and Gurja Belay of the Department of Biology of Addis Ababa University.
Their research was published today in the journal Genome Biology.
One of the guiding principles behind evolution is natural selection; the more an organism is suited to its environment, the more likely it is to survive and pass on its genes. In high-altitude environments, oxygen concentration is low, a condition that can rapidly sicken even kill individuals who are not acclimated.
"As genetic anthropologists," Scheinfeldt said, "we know what patterns of genetic variation we expect to see after positive, or Darwinian, selection has occurred. Then we look for those patterns in the genome and try to make biological sense of what we find.
"The easiest way for us to do this is to look at situations where there's been very strong selective pressure: a disease with a really high mortality rate, or here at high-altitude where there are hypoxic conditions. This kind of situation makes a dramatic difference in terms of who passes on their genes, so it gives us more power to find the genetic signatures left behind."
Pregnant women are especially susceptible to the physiological pressure represented by hypoxia, which influences the birth weight and health of their children. Yet people have been living in the high-altitude regions of the Andes and the Tibetan Plateau for generations, with little apparent ill effect.
Anthropologists, notably, Cynthia Beall, of Case Western University, and Lorna Moore, of Wake Forest University, have therefore extensively documented their physiological traits, trying to understand how these groups offset the problems pregnant women would normally have in hypoxic environments. More recently, geneticists have attempted to correlate these physical traits, or phenotypes, with the genes that are responsible for them, or genotypes.
Researchers have long wanted to add additional populations for comparison, and while the people of the Ethiopian Highlands met the criteria, living at over 3,000 meters above sea level, economic, linguistic and geographic hurdles stood in the way of collecting the data.
"This was an extremely challenging study. The logistics alone, getting permits and permission to do this trip, took us many years," Tishkoff said.
"Sampling from these remote populations was also very difficult," said Simon Thompson, who was part of the group's field team. "Roads were impassable and we spent a lot of time just trying to find the groups that were living at the highest altitude possible."
The researchers compared the genotypes and phenotypes of Amhara participants with those of two other Ethiopian groups that live at lower altitudes. They also compared the Amhara group with Nigerian and European groups that live at or around sea level.
"We make these comparisons," Scheinfeldt said, "to figure out where in the genome the high-altitude group looks distinct from the other groups. Those distinct areas are candidate regions for genetic variants contributing to high altitude adaptation. Two of the top candidates are involved in the HIF-1 pathway, a pathway that is initiated in hypoxic conditions."
Both the Andean and Tibetan populations had mutations related to the HIF-1 pathway as well, but all three groups differed in both genotype and phenotype. One difference in phenotype had to do with hemoglobin, the part of the blood that transports oxygen. Ethiopians and Andeans had hemoglobin levels that were higher than low-altitude populations, but the Tibetans had average levels.
The researchers also discovered a variant in the Ethiopian groups in a gene involved in mitochondrial function. Mitochondria regulate the production of ATP, the chemical cells use for energy, making this gene another interesting candidate for playing a role in adaptation to high altitude.
These differences all seem to play a role in how well a body can maintain homeostasis in low-oxygen conditions, but even seemingly clear advantages, such as higher levels of hemoglobin, are only proxies for more complex phenotypic changes. Putting them together into the big picture of how certain genes translate into a survival advantage will require more focused research based on the Tishkoff lab's findings.
We're chipping away at this question," Scheinfeldt said. "Every little bit helps."
Such research holds promise beyond understanding the history of these populations.
"There's a lot of interest in this kind of research from the biomedical community, in terms of lung physiology and oxygen transport," Tishkoff said. "If one can understand how it is that people who have these genetic adaptations can do fine at these high altitudes while the rest of us suffer, it could help us better understand one of the body's vital systems."
###
This research was supported by funding from the National Institutes of Health and the National Science Foundation.
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Public release date: 20-Jan-2012[ | E-mail |
Share ] Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
PHILADELPHIA -- Over many generations, people living in the high-altitude regions of the Andes or on the Tibetan Plateau have adapted to life in low-oxygen conditions. Living with such a distinct and powerful selective pressure has made these populations a textbook example of evolution in action, but exactly how their genes convey a survival advantage remains an open question. Now, a University of Pennsylvania team has made new inroads to answering this question with the first genome-wide study of high-altitude adaptations within the third major population to possess them: the Amhara people of the Ethiopian Highlands.
Surprisingly, all three groups' adaptations appear to involve different genetic mutations, an example of convergent evolution.
"These three groups took different genetic approaches to solving the same problem," said senior author Sarah Tishkoff, a Penn Integrates Knowledge professor with appointments in the genetics department in Penn's Perelman School of Medicine and the biology department in the School of Arts and Sciences.
In addition to Tishkoff, the research was led by Laura B. Scheinfeldt, a research scientist in the genetics department at the Perelman medical school. Other members of the genetics department who contributed to the research are Sameer Soi, Simon Thompson, Alessia Ranciaro, William Beggs, Charla Lambert and Joseph P. Jarvis.
The Penn team collaborated with Dawit Wolde Meskel, Dawit Abate and Gurja Belay of the Department of Biology of Addis Ababa University.
Their research was published today in the journal Genome Biology.
One of the guiding principles behind evolution is natural selection; the more an organism is suited to its environment, the more likely it is to survive and pass on its genes. In high-altitude environments, oxygen concentration is low, a condition that can rapidly sicken even kill individuals who are not acclimated.
"As genetic anthropologists," Scheinfeldt said, "we know what patterns of genetic variation we expect to see after positive, or Darwinian, selection has occurred. Then we look for those patterns in the genome and try to make biological sense of what we find.
"The easiest way for us to do this is to look at situations where there's been very strong selective pressure: a disease with a really high mortality rate, or here at high-altitude where there are hypoxic conditions. This kind of situation makes a dramatic difference in terms of who passes on their genes, so it gives us more power to find the genetic signatures left behind."
Pregnant women are especially susceptible to the physiological pressure represented by hypoxia, which influences the birth weight and health of their children. Yet people have been living in the high-altitude regions of the Andes and the Tibetan Plateau for generations, with little apparent ill effect.
Anthropologists, notably, Cynthia Beall, of Case Western University, and Lorna Moore, of Wake Forest University, have therefore extensively documented their physiological traits, trying to understand how these groups offset the problems pregnant women would normally have in hypoxic environments. More recently, geneticists have attempted to correlate these physical traits, or phenotypes, with the genes that are responsible for them, or genotypes.
Researchers have long wanted to add additional populations for comparison, and while the people of the Ethiopian Highlands met the criteria, living at over 3,000 meters above sea level, economic, linguistic and geographic hurdles stood in the way of collecting the data.
"This was an extremely challenging study. The logistics alone, getting permits and permission to do this trip, took us many years," Tishkoff said.
"Sampling from these remote populations was also very difficult," said Simon Thompson, who was part of the group's field team. "Roads were impassable and we spent a lot of time just trying to find the groups that were living at the highest altitude possible."
The researchers compared the genotypes and phenotypes of Amhara participants with those of two other Ethiopian groups that live at lower altitudes. They also compared the Amhara group with Nigerian and European groups that live at or around sea level.
"We make these comparisons," Scheinfeldt said, "to figure out where in the genome the high-altitude group looks distinct from the other groups. Those distinct areas are candidate regions for genetic variants contributing to high altitude adaptation. Two of the top candidates are involved in the HIF-1 pathway, a pathway that is initiated in hypoxic conditions."
Both the Andean and Tibetan populations had mutations related to the HIF-1 pathway as well, but all three groups differed in both genotype and phenotype. One difference in phenotype had to do with hemoglobin, the part of the blood that transports oxygen. Ethiopians and Andeans had hemoglobin levels that were higher than low-altitude populations, but the Tibetans had average levels.
The researchers also discovered a variant in the Ethiopian groups in a gene involved in mitochondrial function. Mitochondria regulate the production of ATP, the chemical cells use for energy, making this gene another interesting candidate for playing a role in adaptation to high altitude.
These differences all seem to play a role in how well a body can maintain homeostasis in low-oxygen conditions, but even seemingly clear advantages, such as higher levels of hemoglobin, are only proxies for more complex phenotypic changes. Putting them together into the big picture of how certain genes translate into a survival advantage will require more focused research based on the Tishkoff lab's findings.
We're chipping away at this question," Scheinfeldt said. "Every little bit helps."
Such research holds promise beyond understanding the history of these populations.
"There's a lot of interest in this kind of research from the biomedical community, in terms of lung physiology and oxygen transport," Tishkoff said. "If one can understand how it is that people who have these genetic adaptations can do fine at these high altitudes while the rest of us suffer, it could help us better understand one of the body's vital systems."
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This research was supported by funding from the National Institutes of Health and the National Science Foundation.
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Source: http://www.eurekalert.org/pub_releases/2012-01/uop-prh012012.php
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